Towards Compact Glucose Sensing Using Vibrational Imaging
**** Master Project ****
With diabetes still not having a well-established cure, the regular monitoring of the blood glucose level remains the only way to avoid severe secondary health complication through controlled insulin administration. Today, invasive techniques like the fingerstick testing remain the only solutions allowing precise and reliable blood glucose monitoring for diabetic subjects. The development of a non-invasive blood glucose monitoring technique would improve significantly the life quality of diabetic subjects and help early detection and prevention of diabetes for the healthy ones. In this regard, vibrational spectroscopy, especially Raman scattering, has exhibited substantial promise due to its exquisite molecular specificity and minimal interference of water in the spectral profiles acquired from the blood-tissue matrix. Raman spectroscopy as a probe of vibrational transitions has made a considerable progress thanks to the continuous development of laser sources in the visible range providing high intensity and coherent light. In addition, other vibrational spectroscopy schemes have been derived out of spontaneous Raman spectroscopy including non-linear techniques like stimulated Raman spectroscopy.
The Raman signature of blood Glucose is well known and the detection of glucose concentration in fluid solution have been extensively published and used for industrial applications. The objective of this project is to explore the limits of Raman spectroscopy miniaturization to be used for mobile blood glucose sensing. For this purpose, the student needs to go through the following steps:
The candidate should preferable have the following skills: